Instruct sufferers never to pre-soak, lick, or usually wet OXYCONTIN tablets just before positioning within the mouth, and also to acquire one pill at any given time with ample drinking water to be sure complete swallowing immediately soon after inserting from the mouth. People really should be titrated to discomfort aid Unless of course unmanag

The concomitant usage of ROXICODONE and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, causing enhanced or prolonged opioid effects. These effects may very well be more pronounced with concomitant usage of ROXICODONE and CYP2D6 and CYP3A4 inhibitors, specially when an inhibitor is extra following a secure dose of ROXICODONE i